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KMID : 0603820140200040194
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Journal of Experimental & Biomedical Science
2014 Volume.20 No. 4 p.194 ~ p.200
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Immunostimulating Effects of Polysaccharides of Panax ginseng by Oral Administration into BALB/c Mice
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Kang Mi-Hyeon
Park A-Young
Yang Ae-Hee
Park Ye-Eun
Hong Seung-Hye
Park Gab-Soon
Jung Suk-Yul
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Abstract
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Ginsan, polysaccharide isolated from the root of Panax ginseng C.A. Meyer, has been shown to be a potent immunomodulator, producing several cytokines and stimulating lymphoid cells to proliferate. In this study, ginsan was orally inoculated into BALB/c mice up to 39 days and the activity of immune cells containing macrophages and T cells was analyzed. Moreover, the production of cytokines, e.g., tumor necrotic factor-α (TNF-α), interferon-γ (IFN-γ), GM-CSF and IL-12 was also analyzed. In results, the phagocytosis of macrophages was increased. About 13% cytotoxicity of NK cells was observed in 22 days and 29 days of administration. But, oral administration did not highly affect the proliferation of T cells. In cytokine analysis, 150 mg/kg and 300 mg/kg at 22 days and 29 days showed three times more increase in TNF-α than the controls. IFN-γ showed 1.07 and 1.16 times more increase at 150 mg/kg and 300 mg/kg over 22 days, respectively more than the controls. 32 days of 150 mg/kg and 300 mg/kg induced GM-CSF of about 1.3 times more than the controls. IL-12 was not induced in samples more than the controls. Ginsan could be a potential immunostimulator. Therefore, our study suggests that it can be adapted as an immunostimulator that requires a relatively short oral administration.
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KEYWORD
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Panax ginseng, Ginsan, Macrophage, NK cell, Cytokine
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